HPMV: Human protein mutation viewer — relating sequence mutations to protein sequence architecture and function changes
نویسندگان
چکیده
منابع مشابه
From protein sequence to function.
As genome sequences and protein structures are deciphered, we wish to predict their corresponding functions. Many functions cannot be told from from the sequence, however, although there has been progress in this quest for an impossible Grail. Furthermore, a structure and its corresponding sequence become most interesting when one knows the function. Inductive reasoning, based on the integratio...
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MOTIVATION A basic question in protein science is to which extent mutations affect protein thermostability. This knowledge would be particularly relevant for engineering thermostable enzymes. In several experimental approaches, this issue has been serendipitously addressed. It would be therefore convenient providing a computational method that predicts when a given protein mutant is more thermo...
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Motif3D is a web-based protein structure viewer designed to allow sequence motifs, and in particular those contained in the fingerprints of the PRINTS database, to be visualised on three-dimensional (3D) structures. Additional functionality is provided for the rhodopsin-like G protein-coupled receptors, enabling fingerprint motifs of any of the receptors in this family to be mapped onto the sin...
متن کامل"Hidden" sequence periodicities and protein architecture.
I demonstrate the existence in protein domain sequences of sets of statistically significant periodic signals, characteristic of the architectures of those domains. It is shown that, although the frequencies of the signals characteristic of a particular architecture have definite wave numbers, they can occur in any physical property. The characteristic signals define sequence units, which may c...
متن کاملIntegrative visual analysis of protein sequence mutations
BACKGROUND An important aspect of studying the relationship between protein sequence, structure and function is the molecular characterization of the effect of protein mutations. To understand the functional impact of amino acid changes, the multiple biological properties of protein residues have to be considered together. RESULTS Here, we present a novel visual approach for analyzing residue...
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ژورنال
عنوان ژورنال: Journal of Bioinformatics and Computational Biology
سال: 2015
ISSN: 0219-7200,1757-6334
DOI: 10.1142/s0219720015500286